Topologies of Amyloid fibrils

The first paper of Mohamed Smaoui has been published today in Biophysical Journal. His works describes a methods to build and predict the shape of Amyloid fibrils with multiple proto-filaments.

Vladimir Reinharz presents RNAMoIP at ISMB

Vladimir Reinharz is presenting RNA-MoIP at ISMB 2012. RNA-MoIP is an program that inserts local 3D motifs in RNA secondary structures and that helps you to build 3D models for large RNA molecules.

Seven new languages for Phylo

We released yesterday a new version of our video game Phylo that includes 7 new languages such as Russian, Hebrew, Spanish, Portuguese and Chinese! Check it out at

Phylo in the News

Since our last December's release and the publication of our PLoS ONE paper, our video game Phylo has been broadly reported in the media. Check out below a short list recent articles and radio reports.

Alfred Kam and Chu Wu at Imagine Cup

Alfred Kam and Chu Wu made the Canadian Final of the Imagine Cup competition with a mobile version of our video game Phylo on April 30th.

Phylo at Radio-Canada

Mathieu Dugal interviews Jérôme Waldispühl about our citizen science game Phylo at “La Sphère” on Radio-Canada. Learn about the genesis, the goals and achievements of Phylo!

Phylo at CUSP!

On September 27th, Jérôme Waldispühl will speak of Phylo and the impact of citizen science on Biology at the 2011 CUSP Conference, a conference about the design of everything!

2011 MonBUG symposium

On September 23rd, MonBUG will hold the second binennal Bioinformatics Symposium. The symposium will feature keynotes of Rob Knight and Norbert Perrimon. Register ASAP!

Protein folding made easy

On June 7th, we officially released our tFolder web server. tFolder is a software for predicting coarse grained β-sheet folding pathways. We received a broad media coverage from specialized journals and blogs and we provide below a short paper selection.

McGill-Toronto Computational Molecular and Systems Biology Retreat

On May 13th, we hosted at McGill a one-day bioinformatics retreat with our colleagues from Toronto. The meeting featured two keynotes from Gary Bader (UofT) and Guillaume Bourque (Genome Quebec), ten selected graduate student talks and a poster session. We concluded the retreat with a soccer game... won by UofT!

Remember Philippe Flajolet

It is with a lot of sadness that we heard that Philippe Flajolet passed away on March 22th.

Our protein ensemble structure prediction methods featured at MIT News

MIT news is reporting our ensemble techniques to predict protein structures. The algorithmic foundation of this approach have been developed by Jérôme Waldispühl and co-worker since 2008. The acticle has been written by Larry Hardesty and is entitled “Understanding proteins”.

Solomon Shenker and Jérôme Waldispühl at RECOMB

On March 28-31 2011, Solomon Shenker will give a talk entitled " Efficient traversal of β-sheet protein folding pathways using ensemble models ", and Jérôme Waldispühl will give a talk entitled " An unbiased adaptive sampling algorithm for the exploration of RNA mutational landscapes under evolutionary pressure " at the the 15th Annual International Conference on Research in Computational Molecular Biology (RECOMB 2011).

Jérôme Waldispühl at MIT

On March 2nd 2011, Jérôme Waldispühl will give a lecture entitled " Ensemble Predictions of β-sheet Protein Structures " at the bioinformatics seminar series at computer science and artificial intelligence laboratory at MIT.

Jérôme Waldispühl at Donnelly Center

On February 17th 2011, Jérôme Waldispühl gave a lecture entitled " Ensemble Predictions of β-sheet Protein Structures " at the Donnelly Center at the University of Toronto.

phylo international media coverage

Phylo has been reported worldwide. We cannot obviously provide a link to all articles, so we give below a list of randomly selected posts. Bonne lecture!

phylo professional media coverage

Phylo is a casual game which requests the help of the gamers to solve a biological problem. We have been delighted to see that our work get an echo in both communities. We collected below a couple of links to articles published in gaming magazines and professional media.

phylo media coverage

We have been very pleased to see the interest received by Phylo these last three days. Check out some papers recently published in major media channels:

phylo press release

Phylo, Our human computing framework for comparative genomics is officially released! We published this morning a press release and invite anyone interested in helping science to solve our puzzles. Phylo is now avalailable in two languages: English and French.

Sebastian Will at McGill

On December 3rd 2010, Sebastian Will will visit McGill and give a talk titled “LocARNA-P: Alignment reliabilities for RNA structural analysis” at the School of Computer Science Colloquium. Join us at 3:30pm in McConnell 13!

Alex and Gary awarded at the 2010 URC

Alexander Kawrykow and Gary Roumanis have been awarded at the 2010 McGill Undergarduate Research Conference for their project “Phylo: A human computing framework for comparative genomics”. Congratulations Alex and Gary!

Presentations at the RNA-UNY symposium

On October 8-9 2010, Jérôme Waldispühl gave an selected talk titled “ RNAmutants: A computational framework to explore the mutational landscape of structural RNAs. Theory and applications” at the “RNA-UNY Structure, Function, Application” symposium hosted by the Hudson valley RNA club in Rensselaerville, NY.
Silmutaneously, Vladimir Reinharz presented his work in a poster titled “Reconstruction of RNA tertiary structures from predicted secondary structures and RNA 3D motifs”.

McGill 2010 RNA seminar day

On September 1st 2010, we held at McGill a symposium on “Computational Models for RNA structures”. This symposium featured seminars given by experts from France and Canada and enabled us to get familiarized with the most up-to-date theoretical frameworks to predict and analyze RNA structures.


Our group works in the computational structural biology area broadly defined. We develop theoretical models and algorithms to decipher the relationship between RNA and protein sequences and structures. Predicting molecular structures is not a finality but a mean to understand the genetic code and biological systems.
Do you want to know how the genomic sequences can create molecular systems and activate cellular functions? Are you wondering how molecular structures could influence the evolution of genomes? Do you want to design artificial molecular systems? If you do, join us! These are some of the questions we are trying to answer.